I think you can just about make it in 4 hours if you waste no time, traffic is good and you don't stop anywhere -- and drive like the proverbial bat. My guess is it will take a normal person a few minutes more, at least -- maybe a lot more if traffic is heavy. I'd allow at least 5 hours. I figure the quickest route would be I-15 down to I-215, that to I-10 and back east to Palm Spgs via I-10. Perhaps a "local" (or an Editor) will have a more sure estimate... Bob