A direct run will be in the region of a 7 hour drive by way of I-15. Death valley or the Mojave N.P are popular detours, but other than a long day these are better served with a stop over. You may find Calico ghost town interesting just East of Barstow for a place to take a break.How far/long a drive is the SantaB-LV leg? Anything to see on the way which we would miss with the flight option...?