Welcome to the Great American RoadTrip Forum! The members of this road tripping community who frequent this forum never know quite how to answer a request for the "best" route anywhere. Ask 100 roadtrippers you would easily get 110 different ideas (some of us can't make up our own minds...) so the first thing I would need to know from you is how long will you have? What kinds of things interest you more -- scenic roads or places to hike? Fun roadside diners, etc. You could cover this distance in two days or two months. So... maybe you could share a little more about this trip for us?
Mark