I would expect that the roads will be clear a couple of days (Saturday) after Thursday's snow showers, but what you really need are sun and warmer temperatures to insure such an outcome. The Interstates get the most attention from road crews, see the most traffic and have little or no shading from topography or trees. So if you have any doubts, the route suggested by Google is your best bet. However, if you can devote two days to the drive (in either direction) and the weather is predicted to be relatively warm and sunny, then there is another more relaxed and scenic route that you might want to consider. That would be to take I-390 south from the Rochester area to I-86/NY-17 east to near Corning. There pick up US-15 south through the Susquehanna River valley to Sunbury and PA-61 southeast across the Alleghenies to the Reading area, and then your favorite route into Philly. This will take longer, enough so that you cannot do it in a day, and the weather will have to cooperate, but it is worth looking at either for this trip or another one in the future.

AZBuck