Quote Originally Posted by AZBuck View Post
I will tell you that I have made the reverse adjustment many times without a problem.
I agree with that statement, having done this in reverse a few years ago when I went to South Africa. I don't know what it would be like to go from driving manual transmission to automatic, but I can't imagine it would be that hard of an adjustment, as AZBuck says. The "driving on the other side of the road" issue shouldn't be too big of a deal either. Once you get adjusted, it's fairly natural. You just have to remember that everything is reversed (exit on the right instead of on the left, left turns cross traffic instead of right turns, etc.). Also, be vigilant when you are turning onto roads where there is no traffic -- that is where you could easily revert into UK mode and start driving on the left side of the road again.

My one suggestion would be that on your first night in the USA -- instead of picking up your rental car at the airport -- get a taxi to your hotel and then pick up the car the next morning. Dealing with driving in a foreign land will be much easier after a good night of sleep. Also, try to avoid too much city driving in the first few days.