You can start by checking out two of our good old standbys: a list of places to stop every couple of hours along the major Interstates, and lists of a couple of dozen attractions in each state. Besides that, be sure to stop in at each welcome center as you pass into a new state and ask the invariably helpful staff for their recommendations. Another good source of tips is to get away from the exit ramp fast food joints and head into town for a good sit down meal. Many small to medium sized towns and cities have tourist information bureaus that are another great source of local intel. If nothing else, the locals you'll be talking to will be more interesting and helpful than fry cooks and desk clerks (although I've also gotten great ideas from them on occasion!)
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