Hi Mike,

Here are some must sees along your planned route. Some require some detours :

Suggestions from NYC to Niagara;
Delaware Water Gap, PA-NJ;
1000 Islands Region;
Rock & Roll Hall of Fame in Cleveland, OH
American Classical Music Hall of Fame, Cincinnati, OH
Things to do between ME and Key West, FL;
D.C.;
Historic Harper's Ferry, WV;
Great Smoky Mountains National Park,
Shenandoah NP VA
Blue Ridge Parkway;
50 fun things to do in Atlanta;
Savannah, GA;

Jackson, FL
I assume you mean Jacksonville, FL? Or maybe Jackson, Mississippi?

Happy planning!
Gen