I have driven from Detroit to Cleveland many winter days. There is a good.chance of snow but a poor chance of heavy snow. The really heavy snow falls usually begin the week after Christmas, so a snowfall that closes the turnpike is unlikely.

The thing to realize is that even a minor snowfall can cause traffic to slow to a snails pace until the salt trucks get out. They are pretty good at salting the expressways though, and once salted speeds are back to normal

Two things that can really make a difference are drifting snow and extremely cold temperatures. Salt is ineffective at sub zero. Neither are likely in December. Your biggest concern will be slow driving if it is snowing. Dont believe the Google Maps time estimate. Just take it easy and stay safe.