Hi Steve, and Welcome to the The Great American RoadTrip Forum.

At 600 miles, you certainly have the time to take the scenic route. I am not really familiar with NC, SC and GA, but I would highly recommend taking the coastal road A1A, from Jacksonville to the Port Orange area. That is, of course, if you like beach scenery. If time permits, then take highway 1 to Cape Canaveral, and the expressway to Orlando. If time is running short, you could take I-4 from around Port Orange into Orlando.

Have a great trip.

Lifey