Rather than Columbus or Cincinnati, I'd really think about staying right in Cleveland. The Rock and Roll hall of fame is right on the Lake/Downtown, so simply staying put could give you more time to enjoy yourselves. Both Columbus and Cinci are a fair bit out of the way, and while you could go there with the time you have, I don't know that it would add that much to your experience.

If you decide to go via I-90 and Syracuse, you could take a quick detour to Niagara Falls or stop at the Anchor Bar in Buffalo to try the "original" buffalo wing (the wings are good, but not the best I've had, but its still a worthwhile stop).