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Yes, you can make a great trip to the Grand Canyon and back in two weeks, and while much of it will be driving, you'll be driving through varied (and beautiful) parts of the country with time to make the occasional stop on the way and still have a few days at the Canyon. For a 'northern' route you might want to look at I-90/I-80/I-76 to Denver and then I-70 across the Rockies, using US-191 to head south past Arches National Park and Monument Valley to the Canyon. And for a 'southern' route, I-40/I-44 to St. Louis and then I-70/I-81/I-84 back home (or vice versa). Either of those routes could be driven in 5 days, but allocating 6 to each allows you time to stop at the many attractions along them and still have 2-3 days in northern Arizona.

AZBuck