My husband and I have done parts of that, mentioned in AZBuck's post. Plus we have used I-95 (Hmmmm.....) to get through NC and SC. Posts 7 through 10 show our visits to Kitty Hawk, the Outer Banks, and Charleston's Fort Sumter.
Where in South Florida are you headed? Posts 6 through 13, and Post 15 describe our very recent journeys through Florida.
Donna