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As glc points out, I-70/I-76/I-80 through Pennsylvania and the Midwest are pretty much all Turnpikes. They are also the major artery between the northeast and Chicago. If you are willing to spend a little time rather than pay the cost of the toll roads there are alternatives. The most straightforward one has you adding about 10% (70 miles or so) to your distance but saving nearly all the tolls. That would have you use I-68 west from Hancock, MD to Morgantown, WV and then use I-79 to jog north to I-70 west at Washington, PA. If you wanted an all Interstate route, you would then continue on I-70 to Indianapolis using I-270 around Columbus to the south and I-465 to the northeast around Indianapolis and finish up with I-65 up to the Chicago area. Or, if you don't mind some driving on 4 lane divided (but not limited access) and a few short stretches on two lane highways, you can strike out more directly from Columbus on US-33 north and use OH-117/OH-309 to connect from Huntsville through Lima to US-30 at Delphos and take that the rest of the way to Chicago. If you use the all Interstate route through Indianapolis, then a reasonable place to spend the night would be in the Dayton, OH/Richmond, IN area, whereas if you used the 'Columbus cutoff' then Lima, OH should offer a choice of lodgings.

AZBuck