The big trees are quite a ways north of San Francisco, if you're talking about the famous Redwoods, that is.
Remember you will need to return your rental car and check in at the airport, probably at least 2 hours before departure. Maybe more for an international flight. And LA traffic can be quite congested. I'm not local to LA so I have no idea how long it takes to get from Universal to LAX. Please allow yourself ample time.
I guess I'm the only one here who is thinking "only 2 days in Disneyland??!!" I'm a big kid when it comes to that place. To get the most out of two days, the Main Street area of the park opens up an hour earlier than the rest of the park. So get there an hour early and then check out the map for the rides. Position yourself as close to the major rides you want to do and then run like heck when they open that part of the park. You can easily get a good ride or two in before the lines start getting really long. Anytime there is a parade, the rides are shorter. We usually bang out a few rides during the parades. You can often see at least part of the parade from the ride line anyway. And the crowds really clear out after the night time show is over so, if you stay after that, you can easily bang out a few more rides with fairly short lines.
This time of year is probably a slower time and they aren't open as early/late so some of these tips may not work as well for this time of year.
Enjoy! I think you're gonna have a great time.