I travel US-71 about every six weeks from Kansas City down to my favorite fishing spot of Roaring River State Park outside of Cassville, MO. That stretch is a well-maintained route and is a quick, straight, shot. From the highway you'll see lovely farmland, run through a couple of pig farms (prepare your nose), but otherwise it can be pretty uneventful if you don't leave the highway.
If you're able you'll be near some neat places like Eureka Springs, AR, the Mark Twain National Forest will only be a couple of hours east of Joplin, MO, which has a nationally recognized scenic drive.
You'll run through Lamar, MO which was a stop-over for Wyatt Earp when he was a US Marshal before he headed to Dodge City and points further west in Arizona. Also along the route up you'll find historical marker signs along the highway for places like Harry S. Truman's birthplace, some civil war historical sites, and a few others. Watch the signs for cool stuff.
As you approach Kansas City you'll have some pretty unique picture opportunities in Peculiar, MO (which is the town I actually went to high school in), and while that town used to have a great historic mid-20th century feel, it's become subject to the "strip mall America" that seems to be cropping up all over. There are still some great antique stores there.
Heading up 71 highway into Kansas City can be a confusing trip. The highway turns into the Bruce Watkins Parkway after you pass through a confusing patch of interchanges called the Grandview Triangle in Grandview, MO, a town completely surrounded by Kansas City, MO. There is actually a point on 71 highway where, due to construction, you will exit the highway into one of the more dangerous areas of downtown Kansas City, drive about four blocks, and then get back on the highway (at least this was the case as of about six months ago). But this will take you through the heart of my hometown.
Kansas City is considered the mecca for all things barbeque. FoodTV will suggest places like Arthur Bryant's BBQ, Gates & Sons, or KC Masterpiece. KC locals usually know the best BBQ is found in the suburbs at Jack Stack BBQ with branches in Martin City, MO and Overland Park, KS, Holy Smoke BBQ in Lee's Summit, MO, and Smokehouse BBQ in Gladstone, MO.
If you've got a chance to stop in KC, there are a ton of things to do, almost too many to list here. I suggest the River Market area where just feet from the Missouri River you can often find live music, a great French bistro, and one of the region's most robust farmer's markets on weekends. If you drive by a Hy-Vee grocery store stop in just to try the Shatto milk which is produced at a local dairy farm. It will knock your socks off.
If you have specific questions about Kansas City I'd love to answer them. I've lived here all my life and know a lot of local spots, places to see, things to avoid, and hidden gems.