I went to Alaska last year on a route similar to yours, except going the opposite direction.

Sorry to say, we didn't stop at Talkeetna though that had originally been the plan. But we did stop at Denali National Park, and I highly recommend you take a bus tour of the park to see the scenery and some of the wildlife. I was lucky enough to see moose, mountain goats, grizzly bears, ravens, a fox and even a wolf. It is possible to take a comfy bus ride provided by one of the commercial outfitters at $100 per person, but we took the cheaper option which we found just as good: the shuttle bus service run by the park itself. The cost will vary depending on how far into the park you want to go, up to $37.50 per person. There are rest stops every 1 to 1.5 hours, but you will need to bring your own lunch. Also you will need to reserve in advance. We reserved the day we got there for a tour the next day. I believe you can also reserve on-line or by phone. Supposedly the best chance at seeing wildlife is to take an early morning tour, but we took one for later in the day and came away quite pleased with the experience. The weather can be iffy sometimes though; it's definitely cool, and afternoon showers aren't uncommon in the summer.

At Fairbanks, the University of Alaska has a pretty good museum, so if that's up your alley I recommend that too. We also went to Pioneer Park, but we found the attractions kind of meh, although the Pioneer Air Museum is pretty interesting. Park admission is free, you only have to pay for individual attractions. As well, as a minor roadside stop, you could check out the Alyeska pipeline display.

I have more to say, but first I'd like to know if this is the kind of information you're looking for? And yes, the Milepost is great. We used it a fair bit for planning.