Now - if you make this drive in off days/hours, you may be able to get away with taking I-5 all the way to I-210/CA-210 to I-10. With no significant traffic, this would save you at least half an hour because it's shorter. Most mapping programs will send you that way, but they don't take traffic into consideration.

Even though longer, I would most likely take CA-46/CA-99/CA-58/US-395/I-15/I-215/CA-210 to I-10 just to stay off the LA freeway insanity if nothing else. The only possible bottleneck here is I-15 over Cajon Pass on a Sunday afternoon/evening, with everyone returning to LA from a weekend in Vegas.

Taking AZ-85 to I-8 to avoid Phoenix would be a decent alternate, but it is longer.