Hey, I live in Mineral co, WV and have taken both roads a number of times. I'm not sure where you're starting from, but if you're within proximity of 40 you could take interstate 68 for the easiest drive. If you're roadtripping and want to see some stuff, I recommend WV 50. Both roads cross a lot of interesting scenery. MD 40 is in much better shape. Parts of WV 50 consist of really sharp navigation through steep mountains in Grant county, and those roads have some holes and no longer discernable yellow lines. However, the mountains are beautiful and there are about 5 really interesting towns to see along the way. I personally think 50 is a very interesting drive, and worth the poorish roads and steep mountains.