Thanks for your comments.
I thought we might be being a bit ambitious. We have plans in San Diego, Medford, Seattle and Canada as well as a day or 2 in LA. We have 5 days (and 4 nights) between stops in the south west but other than that we have time booked up with friends.
We would love to go see the Grand Canyon and some other sights around (national parks if possible). Would it be an idea to fly to Vegas (not much interest in the city itself though) and do a 2-3 day trip from there and then fly to medford? Are there other bases we could fly into and hire a car from? we want to fit in as much as we can while we're there but want to balance the travel and the fun :)