Welcome to the RTA Forum!
I think you've got a really good starting point, although I'll throw out a few thoughts.
First, beware of online mapping travel time projections, they tend to really underestimate real world travel times. For example, most of those 7 hour drives you've got heading to Tucson/Roswell/Dallas are really going to be closer to 8 or 9 hour drives.
I will also mention, you're adding some extra miles, and kind of doing a figure 8 by going from I-40 down to San Diego, back up to Disney, and then back along I-10. It would save you a bit of driving to either go to Anaheim before San Diego, or reverse your trip so you do places like Dallas and Tucson before San Diego.
Finally, Is there a reason you've left off the Grand Canyon. It's unusual to be so close to that natural wonder and not include it in your plans.