If you like nature and scenery, look into Shenandoah National Park's Skyline Drive. It runs between Front Royal, VA and Waynesboro, VA, paralleling I-81. Bear in mind it's pretty slow, mostly 30mph plus all the stops you want to make. When we traveled through there 3 years ago, it took us over 5 hours to make the 105 mile drive, but we felt it was well worthwhile! My husband was especially interested in Stonewall Jackson's ties to the area, and both of us enjoyed the scenery. We didn't see much wildlife though we were out early in the day, except for some bees, but we enjoyed it nonetheless.
Donna