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What was posted in this thread 3 years ago is still generally true, but really this is about as straightforward of a drive as you can make.

Its a couple hundred miles of very heavily traveled freeways, where traffic jams would be your most likely problem. Otherwise, the weather is typically pleasant (as GLC mentioned, once every so often there is a little snow, but that's fairly rare, and if their is anyway it would most likely be very light), and you can take comfort in knowing that you'll be sharing the road with several thousand other people - especially if you are traveling on a weekend.