You don't say how long you have for the trip but heading along US395 you have places like Mono, June and Mammoth Lakes and the wonderful Alabama Hills just west of the town of Lone Pine off the Whitney Portal road to Movie Flats road, great for film buffs with great views of Mt Whitney. As you are heading south of Vegas to Hoover Dam and if you have time, then the Grand canyon south rim is an amazing place to spend a night or two.