I'm planning to drive from Montgomery, AL to El Paso, TX this summer. A distance of about 1200 miles each way. I've made this drive before and I broke it up into two days. The first day I drove from Montgomery to Houston and stayed the night there and then drove the rest of the way from Houston to El Paso the second day.
I have a 2010 Nissan Altima with about 34k miles. I've owned it since new and have maintained it properly. I also just put a new set of tires on it.
I also have a 2012 Honda Civic with about 14k miles, also purchased new and maintained properly etc.
Now the Civic gets better gas mileage, 39 to 40mpg highway. The Altima gets 27-29 MPG highway. These are real world numbers from my own experience with each car.
So obviously the Civic is better on gas but the Altima is more comfortable and has more leg room, head room, is better insulated against road noise etc. I've made this drive before in the Altima when it was about 3 months old. Ill be doing quite a bit of driving while in El Paso so fuel economy is still a consideration there, too. Only myself and my 10 year old son will be going on this trip, if that matters.
So which would you choose and why? Comfort over fuel economy?