I drive each year to Florida with a single stop. I prefer to drive all night, and save 8 "kid hours". I leave around 7 pm and arrive in Locust Grove Georgia (between Atlanta and Macon) around 1-2 pm. It is an 18 hour drive with stops (2 kids) but leave about 6 hours to Kissimmee the 2nd day. We stay at the Red Roof Inn, many gas/food/etc. and a large outlet mall 2 min away. Right on I-75. We enjoy the day and go to bed early. We think it is worth it.
Steven