Let me add another one..
I'm real happy with the Toyota Sequoia SUV I use for road tripping. It's got about 80,000 miles on it with no (knock on wood) significant mechanical issues since I bought it new. It's a bigger SUV, and has the pluses and minuses of such a vehicle. It has enough room that 4 people or so fit with LOTS of room in it, plus their gear. 2 people have LOTS of room for everything they need, plus gear. Works really well as a road trip vehicle.
It's big enough I've carried 7 people in it, all with seat belts, and had some room for their gear. It goes OK mileage -- around 20 mpg in the highway at 70 mph (the highest has been around 22 mpg), but less in the city. Interior wise, its got removable back seats, and the 2nd row flips up so if needed you can get up to 6'+ of flat space in the back to sleep in (I bring a futon cushion and its very comfortable).
It's got enough space to pack everything needed for a week's long road trip inside, and a roof rack for additional gear. It's also got electrical outlets in 3 places in the vehicle (the newer ones I think have a built-in voltage inverter to run 110 AC, whereas I use an inverter plugged into the 12 V if needed).
From an environmental standpoint its rated as a ULEV (ultra low emissions vehicle) compared to other V8, and generates around 240 Horsepower which gives it good power. I've got the options of full time all wheel drive if I need it (used fairly frequently for added safety/ control), or going into either L or M full 4 wheel drive (only ever has been used twice...) . I've taken it off pavement numerous times and its performed well on very bumpy dirt roads and out in the middle of no where. I've towed a trailer a couple of times, and it handled a couple thousand pound trailer without problem.
From a safety standpoint its got like 6 airbags on the inside (dual front, plus curtain airbags on the sides), vehicle stability control (anti-rollover) anti lock brakes etc etc. It's also a heavier car, which really helps in any accidents (although I don't want to test that!). The space in the back gives me the volume so I can carry my usual emergency equipment all the time -- tool box, basic supplies, larger first aid kit, etc. It has a full size spare.
Cost -- it isn't cheap, but about the same as other vehicles of the same size. Reliability has been very good, and service costs have been average. I've been pretty impressed with the basic reliability of the vehicle, and getting things repaired under Toyota warranty has been pretty simple (had to replace a broken door handle and remote controlled rear view mirror -- both under warranty since I bought the extended warranty).
Bad points -- I'd like better mileage in the city. I've never been fully comfortable with a full size spare under the car, but I've never had any problems either. It's a bigger car, so the usual slight issues with that (sight lines to corners, watch out for overhangs that are less then 6'4" etc.).
For a road tripping vehicle, if you could get a good one of these used, it might be something to consider. I like it since I've used it for everything from mountain roads to the desert and lots of highway in between, with enough room inside that I can throw stuff in and not worry about overstuffing the car. I no longer have to fill up the back seat as well as the trunk when I go camping (which I did with my sedan). And in a pinch, I can sleep in the back... But basically its that I can carry a couple of other people and gear and emergency supplies I feel more confident about what might occur. I recently did a couple of days through the California deserts -- and with sleeping bags, chairs, ice chest, tarps, extra water, extra clothing, a shovel, matting and etc in the back, we were fairly comfortable tackling some off-pavement sections for 10's of miles away from anything, that we could deal with issues or spent the night if we needed to.
An alternative vehicle might be a mini-van, or family van. This wouldn't have quite the same rough driving capability, but would have equivalent volume inside, and might get somewhat better mileage.