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Nearly that selfsame trip has come up before, and I can't improve on the advice given there. Be especially sure to read down to Judy's recommendations. Two weeks should be enough for what you have in mind, but you can always just keep the thought in the back of your mind that if you get within a couple of days of when you have to be in San Diego, you can always just 'bail' and come inland from the coast, get on I-5 to finish your trip. That way you can just enjoy moseying at your own pace for most of the trip without worrying.

AZBuck