If you're looking for 'reliable' nation-wide hotel/motel chains there are several, but some of the largest are: Accor (Red Roof, Motel 6, Mercure and others); Choice (EconoLodge, Comfort Inns and Suites, Quality Inns and others); Marriott (Marriott, Courtyard, Residence Inn, Fairfield and others); Hilton (Hampton, Homewood Suites, Hilton and others); and Holiday Inn. Each of those chains offers brands that cater to a different portion of the traveling public from the budget-conscious to those seeking luxury. Best Western is another large 'chain' that works on a somewhat different model, franchising the national 'brand' to locally owned and operated properties. I usually suggest that people do a bit of research on the prices and level of services of those chains and if they find one that meets their needs, sign up for that chain's reward program so that they have the possibility of earning themselves a free night's stay along the way. They should all offer web-based booking.
AZBuck