Road Trip Las Vegas to Vancouver

[aDropInTime]

Hi,

me and my friend are flying over to Las Vegas in August.
We're going to rent a car for 2 weeks and are planning a road trip along the West Coast, that is Las Vegas - LA - San Francisco - Porltand - Seattle - Vancouver.
We don't intend to stay in each city for too long, and we don't count Vegas in because we'll be staying at a friend's house anyway.
Our trip starts the moment we hit the road in Vegas to go to LA.
From there on to San Francisco where we intend to stay for 3 days and then on to Portland.
Now here's the question:
How far exactly is it from San Francisco to Portland if we drive straight through without taking long breaks in other towns?
I know that Portland is about 600 miles from Frisco.
Can it be done in 7-8 hours?
And what's the best way to go? I read a lot about the Interstate 5 that goes right up to Portland and even further.

We'll probably stay at a friend's house in Portland, from there we would like to drive up to Seattle and maybe even up to Vancouver and then back including one night at a motel somewhere before heading back to Vegas.

Is this all doable in 2 weeks? and what are the approximate driving times from city to city, esp. from San Francisco to Portland and then on to Seattle and Vancouver?