A laudable goal, that one is...............
Hello valpo,
You betcha I'd consider avoiding Atlanta, and I do so whenever I get the chance. I put my own experiences driving in the ATL metro area right up there (well, down there) with DC/Baltimore, Chicago, and the LA Basin. While late at night would likely be somewhat better, I've been through ATL at 9-10pm and later and it was STILL terrible. It's reasonable to expect Holiday traffic will add materially to the headaches, no matter the time of day/night.
I took a peek at your proposed alternate and I like it. The Alabama Coastal Plain below Montgomery should provide a relatively flat and gentle ride, and both Troy and Dothan are decent small cities. I'd trade I-65 from Nashville to Montgomery and beyond for I-75 from Chattanooga to Atlanta and beyond in a New York Minute.
Foy
I'm with you on the big cities........
........which is why I work hard to avoid them when I can. I can be quite impatient in heavy traffic. My daily commute is 1.6 miles with no stoplights, and has been so for the last 11 years, so I've lost my "edge" when it comes to dealing with traffic.
Sorry to know of your wife's difficulties. I can imagine every sort of event presents challenges with that condition.
Best of luck to you.
Foy