I would agree with Bogart that US-50 can be a very interesting route. But, I also like I-80 which I have driven 30-40 times in the last ten years or so.
The I-80 route would provide a faster access to a couple of sidetrips if you can make time. Virginia City has been a favorite place for years and the Black Rock desert and Guru Drive tops the scale for "Out There" Winnemucca is famous for its paved streets and I like the wide open plains of western Wyoming..
http://www.roadtripamerica.com/slides/guru/25where.jpg