Jon, Just read your thread & thought I'd join in with our recent experiences. Unfortunately there are so many places to go & see that you'll be spoilt for choice but I thought I'd give you the 'heads up' on a couple that we enjoyed.

Vegas - Full on, in your face, 24/7. OK if you like that sort of thing but after 48 hours I have to say we'd had enough. Just a half hour drive away we stayed at the Boulder Dam Hotel, in Boulder, and from there flew over the Dam & into the Grand Canyon, a fantastic experience & one I'd definitely recommend. You can rent out boats or Jet bikes on lake Mead if you have the time, great fun.

Death Valley - Make sure you include at least one night stay here, we stayed at Stovepipe Wells Village and found it to be ok, nothing fancy but very pleasant, especially the nearby sand dunes at sunset. If you're on your Honeymoon make sure to go out & view the night sky, absolutely stunning, I'd never seen stars like it.

Yosemite - We stayed in a log Cabin for 2 nights. BBQ on the rear deck, along with our own hot tub, and were fortunate to watch a Deer & its fawn strolling by. How romantic is that?

Lastly, if you do go to Yosemite, you might want to make your way from there towards Sacramento via the 49 (not too sure of the road designations but you can easily find it in maps.live.com), and make a slight detour off the main road to a small town called Murphy's. There's a hotel there called Murphy's which we stayed at & had dinner & beakfast in the garden, very pleasant. I see you mentioned Wine so I guess the thing that will attract you there are the number of Wineries in the area. We were directed down a little road to one called 'Ironstone' where we took the free tour. Not a wine drinker myself but I have to say it was very interesting & so beautiful. See it here.