US Highway 93 passes through the town of Jackpot just across the Idaho state line and hits I-15 about 20 miles east of Las Vegas with Ely about midway. Ely and Jackpot have the best housing and food options. Wells, not so much. Distance is about 450 miles (and 7 hours) of high desert two lane highway …usually in good condition.
Watch out for icy spots in winter and the shoulder seasons. Pay attention to your tires and your gas gage no matter the season. It is common to see signs: “next gas …100+ miles”. Check your tire pressures before the trip; visually inspect your tires AND THE SPARE. High temperatures are very hard on tires, engine coolant and oil.
Endless vistas and desert scenery suck when your vehicle is dead and the next town is 100 miles away. Carry drinking water.
70 MPH posted open-road limits are typical and car traffic typically moves at 75. Highway 93 is a major semi-truck, snow-bird RV route (lets call em all big rigs). The RV migration is amazing with peak numbers several weeks either side of November 1st and April 1st. Big rigs on a two-lane highway always make for difficult passing situations. Reflections off the pavement and the wide-open country can greatly hamper distance perception resulting in some bizarre passing/not passing decisions.
There is a shortcut of about 45 miles between Ely and Alamo. At the south end of Ely (next to McDonalds), US Highway 6 goes west and intersects highway 318 South. If big rig traffic has been frustrating on US-93 from either end consider taking US-93 through Caliente. There is a heck of a grade on US-93 outside of Ely that discourages big rigs; making that extra 45 miles enticing for a car.
Keep and eye out for wild horses in the high country and bands of desert elk.