: I-435 around Kansas City, I-270 north of St. Louis, I-465 south of Indianapolis, and I-270 north around Columbus. From Columbus head north on I-71 to I-76 east continuing onto I-80 east at the junction with the Ohio Turnpike. I-80 will take you across northern Pennsylvania to Scranton where a short stint on I-81 north/I-380 will connect you with I-84 (again!). Stay on I-84 to the Mass Pike and use that for a couple of exits to I-290/I-495 around Boston. You then have the choice, depending on where in New Hampshire you're headed, to use I-91 north (from Hartford), US-3 north (from Lowell), I-93 north (from Lawrence), or NH-16 north (from Portsmouth).