Today we were on a stretch of road that was called I-81 north and I-77 south. Go figure.
Yep, been on that. And, when you look at an actual map, it does make sense!
The other is near Milwaukee when on the same road you can be going North on I-43, South on I-41, and to top it all off, East on I-894! (The road actually runs straight east-west).