Welcome aboard the RoadTrip America forums.
Your route, parts of it or close to the entire thing, has been coming up quite frequently lately. Rather than try to repeat or paraphrase all that has been written about it, let me direct you to a few of the more current, relevant threads:
San Francisco to Vegas -- What to do?
San Francisco to San Diego
San Francisco to Yosemite to Death Valley to Las Vegas
San Francisco to Grand Canyon to Las Vegas
Los Angeles to San Francisco to Las Vegas
San Francisco to Las Vegas to LA to San Francisco (with some special attention to the Yosemite to Sequoia to Death Valley route selections)
Las Vegas to San Diego (with information about some of the back roads routes).
More detail about Yosemite to Death Valley to Las Vegas
San Francisco Loop RV Field Report with Pictures
San Francisco to Las Vegas