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look up
As was previously mentioned, there are thousands of discussions about 2 week loop trips from San Francisco on this forum - and the links above will give you some real life experiences of what other people have done with their time. Yeehaw has also provided one more example of what you could do. And if that's not enough, use the search function to find countless more ideas.
I think you would be much better off at this point looking through those things and trying to come up with a plan for yourself, rather than continuing to ask for more generic advice.
Once you've got an outline of a plan, then we can offer more suggestions that can make your trip the perfect trip for you.
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