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You are just fine there.
The whole area between the Edward Jones Dome and Busch Stadium from the riverfront to several blocks inland is the heart of downtown and should be quite safe. Plenty of food and entertainment, but I can't recommend any specifics. I'd ask at the hotel about any particular areas to avoid, and for recommendations for specific establishments.
You might want to go to the casino boat.
Hi GLC,
Thank you very much for this information. It has put my mind at ease. We will of course be careful wherever we go.
You should have no problems at all in that part of St. Louis. Your hotel looks to be right next to Laclede's Landing, with plenty of dining/entertainment options. I've eaten there before, but couldn't tell you which exact spot. It's a nice place to walk around and just pick something you like. I know there is the new ballpark village area closer to Busch Stadium too that would be within walking distance, although it was still being built last time I was there.
Thanks Michael for this info.
St. Louis was the only stop on our trip that I had any concerns about - it's good to see that I managed to book the hotel in the right area. The hotel itself seems quite cool: it's an old building (1916) and still functions as a private social and athletics club. Back in the day, Harry S. Truman and Charles Lindbergh used to be members, amongst others.