Only (Just) Possible - If
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Even assuming that you have two full days (48 hours), such a drive is only possible if Tioga Pass (CA-120) is open over the Sierra Nevada. Then you can just do a drive through of Yosemite National Park, exiting to the west and getting on US-395 south at Lee Vining and then going through Death Valley on CA-136/CA-190 and then Ash Meadows Road to Parhump and Las Vegas. Note that even such an optimal route allows very little time for actually stopping in and enjoying the two parks, but at least you could get a few pictures. If Tioga Pass is closed (a distinct possibility in November), then you'd have to go into Yosemite, completely backtrack out to Fresno, circle the mountains to the south through Bakersfield, and come back north on US-395 to enter Death Valley from the west. There is simply no way you can do all that on o two day drive to Las Vegas.
AZBuck
Both are Out of the Question
Well, as noted in my last response, your first option is simply impossible. Such an itinerary would require more than 20 hours of driving over two days, even without stopping for food, fuel and biological necessities. I just don't see how you expect to fit in any time in the park or enjoying such a grueling pace.
Option two is equally impossible, The Pacific Coast Highway is a two lane, twisting, low speed limit road with limited passing opportunities and even fewer options for heading inland while on it. It is a two day drive all by itself. Again, what you propose is 19-20 hours of driving.
The fact is, as you yourself noted originally, that you are pressed for time. That places restrictions on what you can do. I don't see that you are facing up to those very real restrictions. You have posited several itineraries where you try to squeeze in two or three very time consuming side trips. At most you can pick one. Whichever one you choose is up to you, but you can only pick one.
AZBuck