Lots to see in that part of the country
I'm sorry I haven't had the pleasure of traveling there much myself so I can't give you any personal insights. But we have a lot of discussions about those areas so I'll provide you some links to them. Read through them for ideas. Hopefully somebody will pop in here with some more personal knowledge to share.
AZBuck, one of our moderators, wrote a good roadtrip report. While he traveled in other areas that you're not planning on visiting, if you read through this, you should get some good tips.
More great ideas here. And lots of links in the various answers that you should follow for more ideas.
UKCraig, another one of our moderators, also had a great trip in The South and has lots of information you might find useful.
Hope this helps a bit. If you have more specific questions after reading through these, just ask. You almost might want to do a search through the threads here (use the search tool in the green bar above). Happy planning!