Lockport Locks and Erie Canal Cruises [in/near Lockport, NY], warehouse at 210 Market St. off SR 31. Two-hour narrated cruises along the Erie Canal are offered where boats are raised 50 feet to overcome the difference in elevation of the Niagara Escarpment. Passengers cruise past historic sites and five of the original 1825 locks. The Canal Heritage Interpretive Center also is in the warehouse and offers canal exhibits. Food and picnic facilities are available.
A Google search will bring up some more possibilities but this is the only one I'm personally familiar with.