I'm seeking some great brainstorming ideas on where I should go for a brief 5 day road trip in late October or early November. I live in Wisconsin so would like to head south to somewhere a little warmer. I'd like to fly somewhere and then rent a car for 5 days where I can do some type of "loop" trip so as to avoid the one-way drop-off fees. I'm interested in historical stuff, enjoy both rural/wilderness areas and the city, am in good shape so wouldn't mind some day hikes or similar, am a very experienced solo female road tripper and am basically just looking for some ideas.
Areas I'm tossing around now include:
a. Charleston, SC and environs...something like this.
b. Grand Canyon and around ala this article.
c. Maybe somewhere in Kentucky or near the Appalachian trail?
Otherwise I'm open to ideas. Thanks in advance for the help!