My wife and I got back from doing a one way road trip from the DC area to California last week. We used a one way car rental and flew back from California. Along the way we stopped in several state and national parks. The trip was incredible! We kept a blog as we went along. Check it out: http://www.travelblog.org/bloggers/aaron-and-johanna/
Thanks to everyone here who provided advice on planning this trip either directly in response to my questions or indirectly by sharing your own experiences.